Friday, September 27, 2013

SAMTER"S TRIAD - INFORMATION TO KNOW

The disorder is caused by an anomaly in the arachidonic acid cascade, which causes undue production of leukotrienes, a series of chemicals involved in the body’s inflammatory response. When prostaglandin production is blocked by NSAIDS like aspirin, the cascade shunts entirely to leukotrienes, causing overproduction of LT-4 and producing the severe allergy-like effects.
There may be a relationship between aspirin-induced asthma and TBX21, PTGER2, and LTC4S.[3]
In addition to aspirin, other vaso-dilators may induce the same reaction, such as alcohol.


Medication
The preferred treatment now is desensitization to aspirin, undertaken at a clinic specializing in such treatment. Patients who are desensitized then take a maintenance dose of aspirin daily; they have reduced need for supporting medications and fewer asthma and sinusitis symptoms than previously; many have an improved sense of smell.
Treatment formerly focused on relieving the symptoms. Even desensitized people may continue to use nasal steroids, inhaled steroids, and leukotriene antagonists.
Leukotriene antagonists and inhibitors (montelukast, zafirlukast, and zileuton) are helpful in treating Samter’s.
Some patients require oral steroids to alleviate asthma and congestion, and most patients will have recurring or chronic sinusitis due to the nasal inflammation. Desensitization reduces the chance of recurrence.



[edit] Surgery


Occasionally surgery may be required to remove polyps,[4] although they typically recur, particularly if desensitization is not undertaken.



[edit] Diet


A diet low in omega-6 oils (precursors of arachidonic acid), and high in omega-3 oils, may also help.[citation needed]
Some people find relief of symptoms by following a low-salicylate diet such as the Feingold diet. They may need to eliminate the other salicylate-containing foods identified by Swain in 1985 as well.[5] For those who need them, these salicylates are listed in charts in the Feingold Handbook based on level of salicylate measured in the item. Unfortunately, any such list is only a rough guideline since amounts will vary depending on fruit/vegetable variety and where grown; in fact, organic foods have been shown to contain more salicylate than conventional produce because the plant is more likely to be under attack from pests, and salicylate is produced by the plant as protection


1 comment:

  1. “I was walking and my husband was telling me to slow down because he couldn’t keep up with me.”
    Denise F. lived with COPD and chronic asthma for many years. When her quality of life continued to decline, Denise decided to try something different.While being with her horses brought her peace and joy, not being able to breathe made spending time with them challenging. When her grandchildren would visit, she couldn’t even participate in their activities.After the herbal recommendation at the ( multivitamincare org ) Denise my best friend no longer needs oxygen or a walker and has seen many improvements. She can walk, clean her house, go shopping, enjoy a vacation, ride her horses, lift hay bales and do anything she wants to do.Now, when her grandchildren visit, they can ride horses together and make wonderful memories. And, Denise wants to lead the way, “I was walking and my husband was telling me to slow down because he couldn’t keep up with me.”
    If you or someone you love has COPD, emphysema, pulmonary fibrosis or another chronic lung disease and would like to see results like Denise’s, contact them on their website to learn more about your lung disease treatment options how to overcome it.

    ReplyDelete